4,534 research outputs found
The Impact of Halo Properties, Energy Feedback and Projection Effects on the Mass-SZ Flux Relation
We present a detailed analysis of the intrinsic scatter in the integrated SZ
effect - cluster mass (Y-M) relation, using semi-analytic and simulated cluster
samples. Specifically, we investigate the impact on the Y-M relation of energy
feedback, variations in the host halo concentration and substructure
populations, and projection effects due to unresolved clusters along the line
of sight (the SZ background). Furthermore, we investigate at what radius (or
overdensity) one should measure the integrated SZE and define cluster mass so
as to achieve the tightest possible scaling. We find that the measure of Y with
the least scatter is always obtained within a smaller radius than that at which
the mass is defined; e.g. for M_{200} (M_{500}) the scatter is least for
Y_{500} (Y_{1100}). The inclusion of energy feedback in the gas model
significantly increases the intrinsic scatter in the Y-M relation due to larger
variations in the gas mass fraction compared to models without feedback. We
also find that variations in halo concentration for clusters of a given mass
may partly explain why the integrated SZE provides a better mass proxy than the
central decrement. Substructure is found to account for approximately 20% of
the observed scatter in the Y-M relation. Above M_{200} = 2x10^{14} h^{-1}
msun, the SZ background does not significantly effect cluster mass
measurements; below this mass, variations in the background signal reduce the
optimal angular radius within which one should measure Y to achieve the
tightest scaling with M_{200}.Comment: 12 pages, 6 figures, to be submitted to Ap
CMB Lensing Power Spectrum Biases from Galaxies and Clusters using High-angular Resolution Temperature Maps
The lensing power spectrum from cosmic microwave background (CMB) temperature
maps will be measured with unprecedented precision with upcoming experiments,
including upgrades to ACT and SPT. Achieving significant improvements in
cosmological parameter constraints, such as percent level errors on sigma_8 and
an uncertainty on the total neutrino mass of approximately 50 meV, requires
percent level measurements of the CMB lensing power. This necessitates tight
control of systematic biases. We study several types of biases to the
temperature-based lensing reconstruction signal from foreground sources such as
radio and infrared galaxies and the thermal Sunyaev-Zel'dovich effect from
galaxy clusters. These foregrounds bias the CMB lensing signal due to their
non-Gaussian nature. Using simulations as well as some analytical models we
find that these sources can substantially impact the measured signal if left
untreated. However, these biases can be brought to the percent level if one
masks galaxies with fluxes at 150 GHz above 1 mJy and galaxy clusters with
masses above M_vir = 10^14 M_sun. To achieve such percent level bias, we find
that only modes up to a maximum multipole of l_max ~ 2500 should be included in
the lensing reconstruction. We also discuss ways to minimize additional bias
induced by such aggressive foreground masking by, for example, exploring a
two-step masking and in-painting algorithm.Comment: 14 pages, 14 figures, to be submitted to Ap
Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease
Acute respiratory distress syndrome (ARDS) is the most severe form of acute lung injury. It is induced by sepsis, aspiration, and pneumonia, including that caused by SARS coronavirus and human influenza viruses. The main pathophysiological mechanism of ARDS is a systemic inflammatory response. Vagus nerve stimulation (VNS) can limit cytokine production in the spleen and thereby dampen any systemic inflammation and inflammation-induced tissue damage in the lungs and other organs. However, the effects of increased parasympathetic outflow to the lungs when non-selective VNS is applied may result in bronchoconstriction, increased mucus secretion and enhance local pulmonary inflammatory activity; this may outweigh the beneficial systemic anti-inflammatory action of VNS. Organ/function-specific therapy can be achieved by imaging of localized fascicle activity within the vagus nerve and selective stimulation of identified organ-specific fascicles. This may be able to provide selective neuromodulation of different pathways within the vagus nerve and offer a novel means to improve outcome in ARDS. This has motivated this review in which we discuss the mechanisms of anti-inflammatory effects of VNS, progress in selective VNS techniques, and a possible application for ARDS.</jats:p
Theory of Dynamic Stripe Induced Superconductivity
Since the recently reported giant isotope effect on T* [1] could be
consistently explained within an anharmonic spin-charge-phonon interaction
model, we consider here the role played by stripe formation on the
superconducting properties within the same model. This is a two-component
scenario and we recast its basic elements into a BCS effective Hamiltonian. We
find that the stripe formation is vital to high-Tc superconductivity since it
provides the glue between the two components to enhance Tc to the unexpectedly
large values observed experimentally.Comment: 7 pages, 2 figure
Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium
Electrical impedance tomography is an imaging method, with which volumetric images of conductivity are produced by injecting electrical current and measuring boundary voltages. It has the potential to become a portable non-invasive medical imaging technique. Until now, implementations have neglected anisotropy even though human tissues such as bone, muscle and brain white matter are markedly anisotropic. We present a numerical solution using the finite-element method that has been modified for modelling anisotropic conductive media. It was validated in an anisotropic domain against an analytical solution in an isotropic medium after the isotropic domain was diffeomorphically transformed into an anisotropic one. Convergence of the finite element to the analytical solution was verified by showing that the finite-element error norm decreased linearly related to the finite-element size, as the mesh density increased, for the simplified case of Laplace's equation in a cubic domain with a Dirichlet boundary condition
A Reconstruction-Classification Method for Multifrequency Electrical Impedance Tomography
Multifrequency Electrical Impedance Tomography is an imaging technique which distinguishes biological tissues by their unique conductivity spectrum. Recent results suggest that the use of spectral constraints can significantly improve image quality. We present a combined reconstruction-classification method for estimating the spectra of individual tissues, whilst simultaneously reconstructing the conductivity. The advantage of this method is that a priori knowledge of the spectra is not required to be exact in that the constraints are updated at each step of the reconstruction. In this paper, we investigate the robustness of the proposed method to errors in the initial guess of the tissue spectra, and look at the effect of introducing spatial smoothing. We formalize and validate a frequency-difference variant of reconstruction-classification, and compare the use of absolute and frequency-difference data in the case of a phantom experiment
Natural Killer Cell Function and Dysfunction in Hepatitis C Virus Infection
Viruses must continually adapt against dynamic innate and adaptive responses of the host immune system to establish chronic infection. Only a small minority (∼20%) of those exposed to hepatitis C virus (HCV) spontaneously clear infection, leaving approximately 200 million people worldwide chronically infected with HCV. A number of recent research studies suggest that establishment andmaintenance of chronicHCVinfection involve natural killer (NK) cell dysfunction. This relationship is illustrated in vitro by disruption of typicalNK cell responses including both cell-mediated cytotoxicity and cytokine production. Expression of a number of activating NK cell receptors in vivo is also affected in chronic HCV infection.Thus, direct in vivo and in vitro evidence
of compromised NK function in chronic HCV infection in conjunction with significant epidemiological associations between the outcome of HCV infection and certain combinations of NK cell regulatory receptor and class I human histocompatibility linked antigen (HLA) genotypes indicate that NK cells are important in the immune response against HCV infection. In this review, we
highlight evidence suggesting that selective impairment of NK cell activity is related to establishment of chronic HCV infection
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